Partnering Institutions

Performance Sites
Each performance site will administer the following project assessments and procedures:
            Clinical interview with participant and informant
            Memory and thinking assessment
            Collection of blood samples
            Collection of cerebral spinal fluid samples obtained by lumbar puncture (spinal tap)
            Brain magnetic resonance imaging (MRI)
            Brain [18F] fluorodeoxyglucose position emission tomography (FDG PET)
            Brain position emission tomography using Pittsburgh Compound-B (PET-PIB)

Washington University in St. Louis (Coordinating and Performance Site)
Coordinating Site Leader: John C. Morris, MD
Performance Site leader: Randall Bateman, MD
Washington University School of Medicine
Alzheimer’s Disease Research Center
4488 Forest Park Ave., Suite 130
St. Louis, MO 63108-2292

Global Clinical Coordinator: Angela Oliver
Phone: 314-286-2683
Email: olivera@abraxas.wustl.edu

Contact: Wendy Sigurdson
Phone: 314-362-2256
Email: sigurdsonw@neuro.wustl.edu

Columbia University
Site leader: Richard Mayeux, MD
Sergievsky Professor of Neurology, Psychiatry, and Epidemiology
Co-Director, Taub Institute of Research on Alzheimer's Disease and the Aging Brain
Columbia University, College of Physicians and Surgeons
630 West 168th Street
New York, New York 10032

Contact: Dolly Reyes-Dumeyer
Phone: 212-305-5953
Email: dr2290@columbia.edu

Indiana University
Site leader: Bernardino Ghetti, MD
Indiana University
Department of Pathology and Laboratory Medicine
635 Barnhill Drive, MS A 142
Indianapolis, IN 46202

Contact: Francine Epperson
Phone: 317-274-1590
Email: freppers@iupui.edu

University of California, Los Angeles
Site leader: John Ringman, MD
University of California, Los Angeles
10911 Weyburn Ave., Suite 200
Los Angeles, CA 90095

Contact: Ana Isabel Alvarez-Retuerto
Phone: 310-794-0355
Email: aialvarez@mednet.ucla.edu

Brigham and Women’s Hospital–Massachusetts General Hospital
Site leader: Reisa Sperling, MD
Brigham and Women's Hospital
221 Longwood Avenue
Boston, MA 02115

Contact: Meghan Frey
Phone: 617-732-8085
Email: mfrey@partners.org

Brown University–Butler Hospital
Site leader: Stephen Salloway, MD
Butler Hospital
345 Blackstone Blvd.
Providence, RI 02906

Contact: Brittany Clement
Phone: 401-455-6402
Email: bclement@butler.org

University College London
Site leader: Martin Rossor, MD
Dementia Research Centre
Institute of Neurology
University College London
Queen Square
London WC1 3BG
United Kingdom

Contact: Jane Douglas
Phone: 0044 (0)845 155 5000 x723560
Email: jdouglas@drc.ion.ucl.ac.uk

Prince of Wales Medical Research Institute
Site leader: Peter Schofield, PhD, DSc
Prince of Wales Medical Research Institute
Barker St., Randwick
Sydney 2031
Australia

Contact: Dr. Clement Loy
Phone: +61 4 1164 1912
Email: clementl@health.usyd.edu.au

University of Melbourne
Site leader: Colin Masters, MD
Mental Health Research Institute of Victoria
Level 3, Alan Gilbert Building
University of Melbourne
Victoria 3130
Australia

Contact: Alicia Rooney
Phone: +61 3 9389 2923
Email: a.rooney@mhri.edu.au

Edith Cowan University , Perth
Site leader: Professor Ralph Martins
Sir James McCusker Alzheimer’s Disease Research Unit
Edith Cowan University
184 Hampden Road
Nedlands, Western Australia 6009

Contact 1: Kevin Taddei
Phone: +61 (0)8 9347 4200
Phone: k.taddei@ecu.edu.au

Contact 2: Hamid Sohrabi
Phone: +61 (0)8 9347 4200
Email: h_sohrabi_2000@yahoo.co.uk

Subcontractors
Washington University in St. Louis has contracted with the following investigators and institutions to assist in the conduct of the project research:

• Alzheimer’s Disease Cooperative Study (ADCS): Paul Aisen, MD—coordination of clinical and neuropsychological evaluations and monitoring of the acquisition of imaging studies and collection of biological fluids.
• Mayo Clinic, Rochester, MN: Clifford Jack, MD, PhD—MRI site training and standardization.
• University of Michigan: Robert Koeppe, PhD—PET site training and standardization.
• University of Pittsburgh: Chester Mathis, PhD—[11C]PIB site training and standardization.
• San Francisco Veteran’s Administration Medical Center: Michael Weiner, MD— Principal Investigator Alzheimer’s Disease Neuroimaging Initiative (ADNI).

Steering Committee

A steering committee composed of DIAN's principal investigators, associate directors, executive director, core leaders, performance site leaders, prinicpal investigators from ADNI and the ADCS, a bioethicist, autosomal dominant Alzheimer's disease family representatives, representatives of the Food and Drug Administration, and appropriate staff from the National Institute of Aging will govern the research.

Washington University (DIAN Coordinating Center; Performance Site)

• John C. Morris, Director and Principal Investigator
• David M. Holtzman, Associate Director
• Alison M. Goate, Associate Director & Genetics Core Leader
• Virginia Buckles, Executive Director
• Randall Bateman, Clinical Core Leader
• Chengjie Xiong, Biostatistics Core Leader
• Nigel J. Cairns, Neuropathology Core Leader
• Anne M. Fagan, Biomarker Core Leader
• Mark Mintun, Imaging Core Leader
• Dan Marcus, Informatics Core Leader

Other Performance Site Leaders

• Reisa Sperling (Site PI), Massachusetts General Hospital/Brigham and Women's Hospital
• Stephen Salloway (Site PI), Butler Hospital/Brown University
• Richard Mayeux (Site PI), Columbia University
• Bernardino Ghetti (Site PI), Indiana University
• John Ringman (Site PI), University of California, Los Angeles
• Martin Rossor (Site PI), University College, London/Institute of Neurology
• Australian Consortium
  • Peter Schofield (Australian Consortium PI), Prince of Wales Medical Research Institute, Sydney
  • Ralph Martins, Edith Cowan University, Perth
  • Colin Masters, University of Melbourne

Other Steering Committee Members

• Paul Aisen, Alzheimer's Disease Cooperative Study
• Michael W. Weiner, Alzheimer's Disease Neuroimaging Initiative
• Kimberly Quaid, Indiana University Center for Biothics
• David Hawver and Ranjit Mani, representatives from the Food and Drug Administration
• Neil Buckholtz, National Institute on Aging
• Two members of families with dominantly inherited Alzheimer's disease

Resource Allocation Review Committee

A Resource Allocation Review Committee (RARC) will review requests for the use of biospecimens and ecommend approval or disapproval to the Steering Committee.

• David M. Holtzman (Chair), Washington University
• Alison M. Goate, Washington University
• Nigel J. Cairns, Washington University
• Neil Buckholtz, National Institute on Aging
• Douglas Galasko, University of California, San Diego
• Gerard Schellenberg, University of Pennsylvania
• John Q. Trojanowski, University of Pennsylvania

External Advisory Committee

Members of the External Advisory Committee (EAC) will review DIAN annually to evaluate progress, assess the effectiveness of communication among the grant components, and ensure that the conduct of the sites is of the highest possible quality. Current EAC members are:

• Thomas Bird (Chair), University of Washington
• Thomas Montine, University of Washington
• Eric Reiman, Banner Health, Phoenix
• Roger Rosenberg, University of Texas/Southwestern, Dallas
• Peter St. George-Hyslop, University of Toronto

Subcommittees

Subcommittees will address specific topics and operations:

• Data sharing and publications, Richard Mayeux (Chairperson)
• Expansion, Bernardino Ghetti (Chairperson)
• Liaison and patient protection, Martin Rossor (Chairperson)
• Clinical trials, Randall Bateman (Chairperson)

©2009, Washington University