Principal Investigator and Program Director

John C. Morris, MD

The Harvey A. and Dorismae Hacker Friedman Distinguished Professor of
Neurology and Professor of Pathology and Immunology, Physical Therapy, and Occupational Therapy
Washington University in St. Louis School of Medicine
4488 Forest Park Ave., Suite 130
St. Louis, MO 63108
morrisj@abraxas.wustl.edu / Homepage
Phone: 314-286-2881
Fax: 314-286-2763

Dr. Morris leads the Washington University Knight Alzheimer’s Disease Research Center and its two program projects, Healthy Aging and Senile Dementia and the Adult Children Study and directs the Harvey A. Friedman Center for Aging at the University. Dr. Morris has more than 290 peer-reviewed publications and serves on the National Advisory Council for Aging at the National Institutes of Health and the Medical and Scientific Advisory Council for the Alzheimer's Association. Dr. Morris has received both the MetLife and Potamkin Awards in recognition of his research.


Investigators

Paul Aisen, MD

Subcontract Principal Investigator
Director Alzheimer's Disease Cooperative Study
University of California, San Diego
Department of Neurosciences
9500 Gilman Drive, MC 0949
La Jolla, CA 92093
paisen@ucsd.edu / Homepage
Phone: 858-622-2028
Fax: 858-657-0324

Dr. Aisen is director of the Alzheimer’s Disease Cooperative Study (ADCS), the National Institute of Aging–funded Alzheimer’s disease research consortium. Dr. Aisen’s research focuses on inflammatory mechanisms in the brain and the development of new treatment strategies for Alzheimer's disease and other neurodegenerative diseases.


Randall J. Bateman, MD

Clinical Core Leader
Assistant Professor of Neurology
Washington University in St. Louis School of Medicine
600 South Euclid, Box 8111
St. Louis, MO 63110
batemanr@neuro.wustl.edu / Homepage
Phone: 314-362-3429
Fax:314-362-2244

Dr. Bateman’s research focus is on the pathophysiology of Alzheimer’s disease. He developed a novel technique at Washington University that measures the production and clearance rates of CNS proteins. He is program director of the Familial Adult Children Study at Washington University and is an active advisor on the Alzheimer Research Forum early-onset Alzheimer’s disease series.


Nigel Cairns, PhD, FRCPath

Neuropathology Core Leader
Research Associate Professor in the Departments of Neurology and Pathology & Immunology
Washington University in St. Louis School of Medicine
660 South Euclid, Box 8134
St. Louis, MO 63110
cairns@wustl.edu / Homepage
Phone: 314-362-7240
Fax: 314-362-4096

Dr. Cairns co-directs the Alzheimer’s Disease Neuroimaging Initiative (ADNI) Neuropathology Core. His multidisciplinary approach uses histological, biochemical, and cell biological experiments to determine the role of candidate pathological proteins in frontotemporal dementias.


Alison Goate, DPhil

Associate Director, Alzheimer’s Disease Research Center and Genetics Core Leader
The Samuel and Mae S. Ludwig Professor of Genetics in Psychiatry
Washington University in St. Louis School of Medicine
660 South Euclid, Box 8134
St. Louis, MO 63110
goate@icarus.wustl.edu / Homepage
Phone: 314-362-8691
Fax: 314-747-2983

Dr. Goate reported the first causative mutation for autosomal dominant Alzheimer’s disease. Her projects involve high-throughout genotyping on several platforms. Dr. Goate has received both the MetLife and the Potamkin Awards in recognition of her research.


David Holtzman, MD

Associate Director, Alzheimer’s Disease Research Center
Andrew B. and Gretchen P. Jones Professor of Neurology and Molecular Biology & Pharmacology
Washington University in St. Louis School of Medicine
660 South Euclid, Box 8118
St. Louis, MO 63110
Holtzman@neuro.wustl.edu / Homepage
Phone: 314-747-0644
Fax: 314-362-2693

Dr. Holtzman is recognized internationally as a leader in AD biomarker research. He is the chair of the Department of Neurology at Washington University School of Medicine. He has received both the MetLife and Potamkin Awards in recognition of his research.


Clifford Jack, MD, PhD

Subcontract Principal Investigator
Professor of Radiology
Mayo Clinic
Department of Radiology
200 1st St., SW
Rochester, MN 55905
jack.clifford@mayo.edu / Homepage
phone: 507-284-8548
Fax: 507-284-2405

Dr. Jack is engaged in developing and validating magnetic resonance (MR) imaging techniques that will ultimately be clinically useful in the diagnosis and management of Alzheimer's disease and related disorders.


Robert Koeppe, PhD

Subcontract Principal Investigator
Director of the PET Physics Section - Nuclear Medicine division
Department of Radiology
University of Michigan
204 Zina Pitcher Place
3480 Kresge III
Ann Arbor, MI 48109
koeppe@umich.edu / Homepage
Phone: 734-763-9247
Fax: 734-764-0288

Dr. Koeppe's research interests center around the quantitative aspects of positron emission tomography (PET).


Daniel Marcus, PhD

Informatics Core Leader
Director, Neuroinformatics Research Group
Washington University School of Medicine
660 South Euclid, Box 8067
St. Louis, MO 63110
dmarcus@wustl.edu / Homepage
Phone: 314-362-6907
Fax: 314-362-6110

Dr. Marcus has been developing neuroinformatics tools and standards, with a focus on neuroimaging databases and analysis, since 2001. He directs the operation of the Central Neuroimaging Data Archive at Washington University and runs several public data-sharing projects to freely distribute neuroimaging data, including Brainscape and OASIS.


Chester Mathis, PhD

Subcontract Principal Investigator
Director, PET Facility
University of Pittsburgh
PET Facility B-938
UPMC Presbyterian Hospital
200 Lothrop St.,
Pittsburgh, PA 15213-2582
mathisca@upmc.edu / Homepage
Phone: 412-647-0736
Fax: 412-647-0700

Dr. Mathis has a long standing interest in applying synthetic radiochemistry techniques to develop PET radioligands for the serotonin and dopamine neuroreceptor systems. Recent efforts have also included the development of PET radiotracers to image and evaluate amyloid deposition in Alzheimer's disease.


Tammie Benzinger, MD, PhD

Imaging Core Leader
Washington University School of Medicine
660 South Euclid
Box 8131
St. Louis, MO 63110
benzingert@wustl.edu / Homepage
Phone: 314-362-5950
Fax: 314-362-4886

Dr. Benzinger is an expert in the use of imaging to look for biochemical and structural brain changes.


Anne Fagan, PhD

Biomarker Core Leader, Adult Children Study
Research Associate Professor of Neurology
Washington University School of Medicine
660 South Euclid Ave., Box 8111
St. Louis, MO 63110
fagana@neuro.wustl.edu / Homepage
Phone: 314-362-3452
Fax: 314-362-2244

Dr. Fagan’s research focuses on beta amyloid and other Alzheimer’s disease biomarkers in CSF.


Michael Weiner, MD

Co-investigator
Director of the Center for Imaging of Neurodegenerative disease
San Francisco Veteran’s Administration Medical Center;
Professor of Medicine, Radiology, Psychiatry, and Neurology
University of California, San Francisco, U.S.A.
4150 Clement St.
San Francisco, CA 94121
Michael.weiner@ucsf.edu / Homepage
Phone: 415-387-0501
Fax: 415-668-2864

Dr. Weiner has been studying Alzheimer's disease and other neurodegenerative diseases since 1988. His research group has over 70 individuals who are developing and applying new MRI and MR spectroscopy techniques to human brain research. Dr. Weiner heads the Alzheimer’s Disease Neuroimaging Initiative (ADNI).


Chengjie Xiong, PhD

Leader, Biostatistics Core
Research Associate Professor of Biostatistics
Washington University School of Medicine
660 South Euclid, Box 8067
St. Louis, MO 63110
chengjie@wubios.wustl.edu / Homepage
Phone: 314-362-3635
Fax: 314-362-2693

Dr. Xiong has served as an associate editor of the Journal of Alzheimer’s Disease and the Associate Editor of Biostatistics for Alzheimer’s Disease and Associated Disorders. Dr. Xiong’s research interests include statistical design of experiments, linear and nonlinear mixed models, longitudinal data analysis, survival analysis and reliability, categorical data analysis, order restricted statistical inferences, and their applications in medicine, biology, education, and engineering.