©2009, Washington UniversityPartnerinstitute
DIAN-Standorte
Jeder DIAN-Standort führt die folgenden Befragungen und Untersuchungen durch:
- Klinische Befragung des Teilnehmers und seiner Begleitperson
- Testung von Gedächtnis und Denkvermögen
- Blutentnahme
- Entnahme von Gehirn-Rückenmarks-Flüssigkeit durch Lumbalpunktion
- Magnetresonanztomographie (MRT) des Gehirns
- Fluordeoxyglucose-Positronen-Emissionen-Tomographie (FDG-PET) des Gehirns
- Positronen-Emissionen-Tomographie mithilfe des Pittsburgh Compound-B (PIB-PET)
Washington University in St. Louis (Coordinating and Performance Site)
Coordinating Site Leader: John C. Morris, MD
Performance Site leader: Randall Bateman, MD
Washington University School of Medicine
Knight Alzheimer’s Disease Research Center
4488 Forest Park Ave., Suite 130
St. Louis, MO 63108-2292
Global Clinical Coordinator: Angela Oliver
Phone: 314-286-2683
Email:
olivera@abraxas.wustl.edu
Contact: Wendy Sigurdson
Phone: 314-362-2256
Email: sigurdsonw@neuro.wustl.edu
Columbia University
Site leader: Richard Mayeux, MD
Sergievsky Professor of Neurology, Psychiatry, and Epidemiology
Co-Director, Taub Institute of Research on Alzheimer's Disease and the Aging Brain
Columbia University, College of Physicians and Surgeons
630 West 168th Street
New York, New York 10032
Contact: Dolly Reyes-Dumeyer
Phone: 212-305-5953
Email: dr2290@columbia.edu
Indiana University
Site leader: Bernardino Ghetti, MD
Indiana University
Department of Pathology and Laboratory Medicine
635 Barnhill Drive, MS A 142
Indianapolis, IN 46202
Contact: Francine Epperson
Phone: 317-274-1590
Email: freppers@iupui.edu
University of California, Los Angeles
Site leader: John Ringman, MD
University of California, Los Angeles
10911 Weyburn Ave., Suite 200
Los Angeles, CA 90095
Contact: David Wharton
Phone: 310-794-0355
Email:dwharton@mednet.ucla.edu
Brigham and Women’s Hospital–Massachusetts General Hospital
Site leader: Reisa Sperling, MD
Brigham and Women's Hospital
221 Longwood Avenue
Boston, MA 02115
Contact: Dana Sapir
Phone: 617-525-9554
Email: dsapir@partners.org
Brown University–Butler Hospital
Site leader: Stephen Salloway, MD
Butler Hospital
345 Blackstone Blvd.
Providence, RI 02906
Contact: Michelle L. Gardner, MA
Phone: 401-455-6403
Email: MLGardner@butler.org
University of Pittsburgh
Site leader: Eric McDade, D.O.
Alzheimer Disease Research Center
University of Pittsburgh School of Medicine
4-West Montefiore University Hospital
200 Lothrop Street
Pittsburgh, PA 15213
Contact: Snezana Ikonomovic, MD
Phone: 412-692-2700
Email: ikonomovics@upmc.edu
Eric McDade, D.O.
Phone: 412-692-2732
Email: mcdadee@umpc.edu
University College London
Site leader: Martin Rossor, MD
Dementia Research Centre
Institute of Neurology
University College London
Queen Square
London WC1 3BG
United Kingdom
Contact: Jane Douglas
Phone: 0044 (0)845 155 5000 x723560
Email: jdouglas@drc.ion.ucl.ac.uk
Neuroscience Research Australia
Site leader:
Peter Schofield, PhD, DSc
Neuroscience Research Australia
Barker St., Randwick
Sydney 2031
Australia
Contact: Dr. Bill Brooks
Phone: +61 2 9399 1101
Email: w.brooks@NeuRA.edu.au
Contact 2: Mirelle D'Mello
Phone: +61 2 9399 1825
Email: m.dmello@NeuRA.edu.au
University of Melbourne
Site leader:
Colin Masters, MD
Mental Health Research Institute of Victoria
Level 3, Alan Gilbert Building
University of Melbourne
Victoria 3130
Australia
Contact: Tabitha Nash
Phone: +61 (0) 3 8344 1859
Email: t.nash@mhri.edu.au
Edith Cowan University , Perth
Site leader:
Professor Ralph Martins
Sir James McCusker Alzheimer’s Disease Research Unit
Edith Cowan University
184 Hampden Road
Nedlands, Western Australia 6009
Contact 1: Kevin Taddei
Phone: +61 (0)8 9347 4200
Phone: k.taddei@ecu.edu.au
Contact 2: Hamid Sohrabi
Phone: +61 (0)8 9347 4200
Email: h.sohrabi@ecu.edu.au
German Center for Neurodegenerative Diseases (DZNE) Munich
Site leader: Adrian Danek, MD
Professor of Cognitive Neurology
German Center for Neurodegenerative Diseases (DZNE) Munich, and
University Hospital Ludwig-Maximilians-Universität (LMU) Munich
Marchioninistr. 15
D-81377 München, Germany
Email: adrian.danek@dzne.de
Contact: Petra Mehlhorn
Phone: +49 89 7095-4828
German Center for Neurodegenerative Diseases (DZNE) Tübingen
Site leader: Mathias Jucker, PhD
Professor of Cellular Neurology
German Center for Neurodegenerative Diseases (DZNE) Tübingen, and
Hertie-Institute for Clinical Brain Research, University of Tübingen
Otfried-Müller Strasse 27
D-72076 Tübingen, Germany
E-mail: mathias.jucker@dzne.de
Contact: Simone Eberle
Phone +49-7071-29-86863
E-mail: simone.eberle@uni-tuebingen.de
Subcontractors
Washington University in St. Louis has contracted with the following investigators and institutions to assist in the conduct of the project research:
Steering Committee
A steering committee composed of DIAN's principal investigators, associate directors, executive director, core leaders, performance site leaders, prinicpal investigators from ADNI and the ADCS, a bioethicist, autosomal dominant Alzheimer's disease family representatives, representatives of the Food and Drug Administration, and appropriate staff from the National Institute of Aging will govern the research.
Washington University (DIAN Coordinating Center; Performance Site)
- John C. Morris, Director and Principal Investigator
- David M. Holtzman, Associate Director
- Alison M. Goate, Associate Director & Genetics Core Leader
- Virginia Buckles, Executive Director
- Randall Bateman, Clinical Core Leader
- Chengjie Xiong, Biostatistics Core Leader
- Nigel J. Cairns, Neuropathology Core Leader
- Anne M. Fagan, Biomarker Core Leader
- Tammie Benzinger, Imaging Core Leader
- Dan Marcus, Informatics Core Leader
Other Performance Site Leaders
- Reisa Sperling (Site PI), Massachusetts General Hospital/Brigham and Women's Hospital
- Stephen Salloway (Site PI), Butler Hospital/Brown University
- Richard Mayeux (Site PI), Columbia University
- Bernardino Ghetti (Site PI), Indiana University
- John Ringman (Site PI), University of California, Los Angeles
- Martin Rossor (Site PI), University College, London/Institute of Neurology
- Australian Consortium
- Peter Schofield (Australian Consortium PI),Neuroscience Research Australia, Sydney
- Ralph Martins, Edith Cowan University, Perth
- Colin Masters, University of Melbourne
Other Steering Committee Members
- Paul Aisen, Alzheimer's Disease Cooperative Study
- Michael W. Weiner, Alzheimer's Disease Neuroimaging Initiative
- Kimberly Quaid, Indiana University Center for Biothics
- David Hawver and Ranjit Mani, representatives from the Food and Drug Administration
- Neil Buckholtz, National Institute on Aging
- Two members of families with dominantly inherited Alzheimer's disease
Resource Allocation Review Committee
A Resource Allocation Review Committee (RARC) will review requests for the use of biospecimens and ecommend approval or disapproval to the Steering Committee.
- David M. Holtzman (Chair), Washington University
- Alison M. Goate, Washington University
- Nigel J. Cairns, Washington University
- Neil Buckholtz, National Institute on Aging
- Douglas Galasko, University of California, San Diego
- Gerard Schellenberg, University of Pennsylvania
- John Q. Trojanowski, University of Pennsylvania
External Advisory Committee
Members of the External Advisory Committee (EAC) will review DIAN annually to evaluate progress, assess the effectiveness of communication among the grant components, and ensure that the conduct of the sites is of the highest possible quality. Current EAC members are:
- Thomas Bird (Chair), University of Washington
- Thomas Montine, University of Washington
- Eric Reiman, Banner Health, Phoenix
- Roger Rosenberg, University of Texas/Southwestern, Dallas
- Peter St. George-Hyslop, University of Toronto
Subcommittees
Subcommittees will address specific topics and operations:
- Data sharing and publications, Richard Mayeux (Chairperson)
- Expansion, Bernardino Ghetti (Chairperson)
- Participant liaison, Martin Rossor (Chairperson)
- Clinical trials, Randall Bateman (Chairperson)
©2009, Washington University